Pesquisa LDL Calculator Implementation of the Martin-Hopkins equation to estimate cLDL 12 Outubro 2024 Values (mg/dL) TC HDL Tg Results cLDL (mg/dL) - Martin‐Hopkins Results cLDL (mg/dL) - Friedewald Calculate c LDL Rationale lthough there are several methods for determining LDL concentration, many clinical laboratories estimate the LDL-C value, with the Friedewald formula being the most commonly used method. The Friedewald formula is based on subtracting non-HDL cholesterol from the change in VLDL in a ratio of 1:5 according to triglycerides (Tgs). This fixed ratio is an approximation and leads to inaccuracies in the estimation of LDL-C which could have an impact on clinical practice and therapeutic decisions. In addition, with Tgs above 400mg/dL and dysbetalipoproteinemia, this formula cannot be applied. Several studies have described the fact that the Friedewald formula underestimates cLDL results, especially in patients with hypertriglyceridemia (Tgs ≥ 150mg/dL), diabetes mellitus, alcoholic liver disease and chronic kidney disease on dialysis. Underestimation can be problematic and may lead to preventive and therapeutic care being postponed. In 2013, Martin et al suggested a formula similar to Friedewald's, in which the estimate of VLDL cholesterol is calculated by dividing Tgs by an adjustable factor that depends on the value of non-HDL cholesterol and Tgs. Validation studies, including in Portugal, have shown its superiority to the original Friedewald formula in estimating cLDL concentration in various populations. S. Martin, M. Blaha, M. Elshazly, et al. Comparison of a Novel Method vs the Friedewald Equation for Estimating Low‐Density Lipoprotein Cholesterol Levels From the Standard Lipid Profile. JAMA., 310 (2013), pp. 2061-2068 http://dx.doi.org/10.1001/jama.2013.280532 Artigos recentes